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What is Krilex?

krilex-150-BottleThe curative power of the sea.

A gift from the sea.

An excellent alternative for those who do not eat fish regularly.

A Quebec discovery that helps to maintain our quality of life.

Krilex is a natural health product made integrally of lyophilized whole krill offered encapsulated. Offered in capsules of plant origin, Krilex assures maximal biodisponibility.

Krilex is made of 100% Canadian whole krill of the specie Euphausia pacifica, caught in the cold waters of North Pacific ocean, in Canadian territory and in a non-contaminated zone. All necessary precautions are taken to keep the krill whole and intact: this is why Krilex is integral krill. Freshly caught krill is immediately frozen on the boat, then lyophilized at very low temperature without using heat. Lyophilization is the best method for the conservation of foods and natural health products. Thus, lyophilized whole krill is kept raw, concentrated and undenatured in such a way that the final product conserves all the nutritional and nutraceutical properties of freshly caught krill.

One has to combine several terrestrial foods or natural health products to reach the same nutritive value and variety of essential nutrients. By consuming Canadian lyophilized whole krill, we get, for example, what salmons eat to get their omega-3 fats and other nutrients essential for their growth, their pink color and their health maintenance. To take Krilex, it is to go to the source directly.

DOSAGE AND SPECIFIC RECOMMENDED USES

Ingredients Posology Specific Recommended Uses
Beta-carotene 1 capsule Source of vitamin A that helps to maintain eyesight, skin, membranes and immune functions.Source of vitamin A that helps the development and the maintenance of the bones and teeth.
iodine 1 capsule Helps the good functioning of the thyroid gland
selenium 3 capsules Antioxidant maintaining good health
copper 6 capsules Helps the formation and repair of connective tissues. Helps the formation of red blood cells.
iodine 10 capsules Helps to prevent a deficiency in iodine.

DESCRIPTION OF THE LICENSED ACTIVE INGREDIENTS

Each capsule of Krilex contains lyophilized whole krill providing EPA and DHA omega-3, iodine, selenium, copper and beta-carotene as the licensed active ingredients. All together, they contribute to maintain good health. The main characteristics of each licensed active ingredient are described below.
EPA and DHA omega-3 fatty acids.

Krilex presents EPA and DHA omega-3 fatty acids in diverse chemical forms including phospholipids, triglycerides and free fatty acids, which multiply available molecular species of omega-3 fatty acids that are active metabolically in the body in comparison with fish oil extracts which, for most of them, are presented in triglyceride forms only.

Moreover, Krilex is essential to the balance between omega-3 and omega-6 fats. For example, Krilex contains more omega-3 fats than omega-6 fats, that is 20 times more omega-3 fats than linoleic acid, an omega-6 fatty acid that is abundant in our industrial diet, the latter inhibiting the activity of omega-3 fats by competition. Contrary to Krilex, fish rich in omega-3 fats are also rich in omega-6 fats (1). In consequence, Krilex is a better source of omega-3 fats than fish, especially fish from farming fisheries(1,2).

Considering that our diet provides an excess of omega-6 fats, that the omega-6/omega-3 ratio in Western diet is unbalanced and that the latter increases the risk of chronic diseases (3-7), regular consumption of Krilex is an option that helps to restore the equilibrium between incorporated omega-3 and omega-6 fats. As a consequence, it favors a better balance between the lipid superhormones which derive from them and which play a determinant role in maintaining good health.

More than 5,000 scientific publications explain the health benefits of marine products rich in omega-3 fats. Marine omega-3 fats have attracted considerable interest for two main reasons:

1- Fish consumption is of vital importance during all phases of life. EPA and DHA fatty acids are cell constituents. DHA is particularly abundant in brain cells, the neurons, and in nerve relay stations, the synapses. These fatty acids are also found in visual receptors (retina, cones, rods), in adrenals and sexual glands. DHA is part of the most biochemically active tissues of our body (8-20).

2- Studies around the world have confirmed that the omega-3 fatty acids are necessary for the good functioning of vital systems (nervous, cardiovascular, gastrointestinal, respiratory, reproductive and immune). They have favorable effects on the composition of cell membranes as well as on numerous biochemical processes of the body, notably the regulation of arterial tension, vascular elasticity, immune and anti-inflammatory reactions, and platelet aggregation (16-63).

More specifically, the beneficial effects of marine omega-3 fatty acids have been demonstrated in primary and secondary prevention of many pathologies : coronary disease, cardiac arrhythmia, atherosclerosis, thrombosis, embolism, hypertension, hypercholesterolemia, diabetes type 2, inflammatory diseases (arthritis, rheumatism, acne, eczema, psoriasis, ulcerative colitis, Crohn’s disease, etc.). Certain patients with kidney diseases, chronic pulmonary obstruction, cancer or behavioral troubles have experienced benefits by consuming omega-3 EPA and DHA (21-63).

Iodine

Iodine contributes to the good functioning of the thyroid gland (64).
Iodine is essential for the formation of thyroid hormones which, in turn, are necessary for the good functioning of the brain (65-68). Clinical use of iodine and of thyroid hormones for decades has confirmed their beneficial effects for cognition and mental health. Thyroid hormones and derivatives distribute iodine in the entire body where it contributes to the regulation of cell metabolism and to the inflammatory response (65-68,77). Furthermore, iodine is a powerful antioxidant, the first antioxidant to be used by cells since the beginning of aerobic life (78,70). Iodine as well as thyroid hormones and their derivatives are powerful antioxidants and protect the precious omega-3 fatty acids from deterioration by peroxidation(67,80-83). In fact, they are more powerful than other antioxidants such as vitamin E, glutathione and vitamin C (84-89). Several scientific studies have reported the beneficial effects of the antioxidant activity of iodides in diverse chronic diseases (90-105).

Selenium

Selenium is a trace element which antioxidant activity helps to maintain good health (64). It is an essential component of diverse families of enzymes involved in repair reactions and in the regulation of thyroid hormones (67,68,106). It mobilizes iodides from thyroid hormones allowing them to execute their antioxidant activity (67,68,106).

Copper

Copper is a metallic trace element that helps the formation and repair of connective tissues (64). It helps also the formation of red blood cells (64). Scientific and medical studies have demonstrated that it plays a crucial physiological role in the formation of neurotransmitters as well as in the formation of myelin, the sheet covering the peripheral nerves and the brain white matter (107).

Beta-carotene

Beta-carotene is a source of vitamin A that helps to maintain eyesight, skin, membranes and immune functions. It contributes also to the development and the maintenance of bones and teeth (64).
Table 1 shows the importance of Krilex as an incomparable source of iodine, selenium and copper as compared to common food groups and to fish oils. For example, Krilex is the food product that contains the highest quantity of iodine per gram; consuming 2-3 grams a day (that is 6-10 capsules) meets the averaged daily iodine requirements for an adult man. In comparison, 250 grams of fish, 1,500 grams of meat, 1,670 grams of cereals, 4,100 grams of vegetables, etc., must be eaten per day to obtain the same result. The same reasoning applies for selenium and copper. Taking into account the importance of beta-carotene and EPA and DHA omega-3 as well, the relevant point is that, whatever the quantity consumed within the recommended doses, Krilex can help considerably in meeting nutritional requirements of certain brain selective nutrients

Table 1. Iodine, selenium and copper contents of diverse food groups and natural health products1

Food groupd and natural health products Iodine Selenium Copper
Concentration (microgram per gram) Amount needed2 (gram per day) Concentration (microgram per gram) Amount needed3 (gram per day) Concentration (microgram per gram) Amount needed4 (gram per day)
Krilex 52 2 4 25 4,200 60
Fish 0.5-1.1 150 0.1-0.3 660 50-200 3,100
Eggs 0.53 190 0.11 900 100 2,500
Shellfish 0.10-0.28 680 0.3-0.4 300 200-400 900
Milk 0.15 6,670 0.1-1.0 5,500 20 12,500
Nuts 0.05-0.1 1,500 0.01-0.07 5,500 200-500 900
Meat 0.05-0.1 1,500 0.01-0.14 5,000 100-300 1,700
Cereals 0.06 1,670 0.03-0.09 2,200 30-200 4,800
Vegetables 0.01-0.03 4,200 0.01-0.03 6,700 60-200 2,700
Pulses 0.02 5,000 0.02-0.10 3,000 500-2,000 300
Fruit 0.01-0.05 6,000 0.01-0.05 6,000 30-200 4,800
Fish oil 0 Not applicable 0 Not applicable 0 Not applicable

1 Modified from reference 107, p. 133, 137, 141, except for the natural health products.

2 Average amount of the food group or natural health product needed to satisfy the daily iodine requirement, which has been averaged to a single, commonly accepted value of 100 micrograms per day for adult, non-pregnant humans.

3 Average amount of the food group or natural health product needed to satisfy the daily selenium requirement, which has been averaged to a single value of 100 micrograms per day.

4 Average amount of the food group or natural health product needed to satisfy the daily copper requirement, which has been averaged to a single value of 2,500 microgram per day.

Brain selective nutrients

The licensed active ingredients of Krilex are part of a group of nutrients that are selective for the brain. Brain selective nutrients include certain micronutrients (iodine, iron, selenium, copper, zinc), vitamins (vitamin A and D), and marine omega-3 fatty acids (EPA and DHA) (107,108). They are necessary for the whole body, but more so for the development and the good functioning of the human brain. They help to maintain good mental health at all ages (107,108).

The majority of brain selective nutrients are of marine origin. Fatty fishes and shellfish (mollusks and crustaceans) are among the best sources of brain selective nutrients (107,108). Among crustaceans, whole krill holds a primordial place. Situated at the basis of the marine food chain, krill is a plankton used as a food by multiple animal species (109,110). Hence, shellfish and fatty fishes find their nutrients from plankton, including whole krill.

More than a billion persons today show an under-optimal cerebral function simply because they have an inadequate supply of iodine, iron and EPA and DHA omega-3 fatty acids (65,66,107). The brain is very vulnerable to a functional deficiency of these nutrients (107). Therefore, a diet rich in brain selective nutrients appears to be a potentially beneficial strategy to sustain good mental health.

Cumulative evidence suggests that the consumption of whole marine foods containing an optimal combination of brain selective nutrients appears to be more advantageous than the supplementation of fish oil extracts (107, 111-116). In occurrence, since DHA is the main omega-3 fatty acid involved in neuronal activity, recent studies examined closely its neuroprotective role during aging (117-119). Despite its biological importance, clinical analyses on humans could not establish a clear and convincing link between cognitive decline and DHA levels in the blood and in the brain (111,113). Furthermore, supplementation of DHA-rich oil, alone or in combination with EPA, provided little or no benefits on the progression of cognitive decline with aging and on dementia (111,113,120,121). In conclusion, the neuroprotective effect of fatty fish and shellfish (including crustaceans like whole krill) seems attributable to the cooperation between brain selective nutrients with other bioactive substances such as niacin, vitamin B12 and antioxidants (111,113,114). Similarly, other studies have shown that the consumption of whole plant foods of terrestrial origin providing antioxidants and polyphenols helps to maintain good mental health (122). Therefore, it is plausible to consider that the consumption of whole plant foods of terrestrial origin in concert with marine food products contributes to maintain good general health including mental health.